循環器内科
研究・業績
循環器内科 研究・業績
Performance
心臓病センター センター長 稲垣 正司 Masashi Inagaki
論文（2005年以降）
1. Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M. Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats. Journal of Physiological Sciences 70(1):11, 2020.
2. Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M. Chronic vagal nerve stimulation exerts additional beneficial effects on the beta-blocker-treated failing heart. Journal of Physiological Sciences 69(2):295-303, 2019.
3. Yamamoto H, Kawada T, Shimizu S, Uemura K, Inagaki M, Kakehi K, Iwanaga Y, Fukuda K, Miyamoto T, Miyazaki S, Sugimachi M. Ivabradine does not acutely affect open-loop baroreflex static characteristics and spares sympathetic heart rate control in rats. International Journal of Cardiology 257:255-261, 2018.
4. Zheng C, Li M, Kawada T, Inagaki M, Uemura K, Sugimachi M. Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure. Physiological Reports 5(21): e13497, 2017.
5. Uemura K, Inagaki M, Zheng C, Kawada T, Li M, Fukumitsu M, Sugimachi M. Acute ivabradine treatment reduces heart rate without increasing atrial fibrillation inducibility irrespective of underlying vagal activity in dogs. Heart and Vessels 32(4):484-494, 2017.
6. Uemura K, Inagaki M, Zheng C, Li M, Kawada T, Sugimachi M. A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities. Heart and Vessels 30(4):516-526, 2015.
7. Aiba T, Noda T, Hidaka I, Inagaki M, Katare RG, Ando M, Sunagawa K, Sato T, Sugimachi M. Acetylcholine Suppresses Ventricular Arrhythmias and Improves Conduction and Connexin-43 Properties During Myocardial Ischemia in Isolated Rabbit Hearts. Journal of Cardiovascular Electrophysiology 26(6):678-685, 2015.
8. Miyamoto T, Nakahara H, Ueda S, Manabe K, Kawai E, Inagaki M, Kawada T, Sugimachi M. Periodic Breathing in Heart Failure Explained by Dynamic and Static Properties of Respiratory Control. Clinical Medicine Insights: Cardiology 9(Suppl 1):133-142, 2015.
9. Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M. Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. European Journal of Heart Failure 16(10):1056-1065, 2014.
10. Seo K, Inagaki M, Hidaka I, Fukano H, Sugimachi M, Hisada T, Nishimura S, Sugiura S. Relevance of cardiomyocyte mechano-electric coupling to stretch-induced arrhythmias: Optical voltage/calcium measurement in mechanically stimulated cells, tissues and organs. Progress in Biophysics &Molecular Biology 115(2-3):129-139, 2014.
11. Uemura K, Inagaki M, Zheng C, Li M, Kawada T, Sugimachi M. A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities. Heart and Vessels 30(4):516-526, 2014.
12. Miyamoto T, Bailey DM, Nakahara H, Ueda S, Inagaki M, Ogoh S. Manipulation of central blood volume and implications for respiratory control function. American Journal of Physiology - Heart and Circulatory Physiology 306(12):H1669-1678, 2014.
13. Zheng C, Li M, Kawada T, Uemura K, Inagaki M, Sugimachi M. An intelligent flow control system for long term fluid restriction in small animals Conference proceedings - IEEE engineering in medicine and biology society 2013:4533-4536, 2013.
14. Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi M. Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. Circulation Journal 77(10):2519-2525, 2013.
15. Uemura K, Kawada T, Inagaki M, Sugimachi M. A minimally invasive monitoring system of cardiac output using aortic flow velocity and peripheral arterial pressure profile. Anesthesia & Analgesia 116(5):1006-1017, 2013.
16. Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M. Medetomidine, an α (2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control. Circulation Journal 76(1):152-159, 2012.
17. Miyamoto T, Inagaki M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M. Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes. European Journal of Applied Physiology112(1):237-251, 2012.
18. 阿部誠, テルマ・スガイ・ケイコ, 吉澤誠, 本間経康, 杉田典大, 清水一夫, 後藤萌, 稲垣正司, 杉町勝, 砂川賢二. 植込み型除細動器用致死性不整脈検出アルゴリズムの高速・高精度化．生体医工学49:932-938, 2011.
19. Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change. Conference proceedings - IEEE engineering in medicine and biology society 2010:5205-5208, 2010.
20. 阿部誠, テルマ・スガイ・ケイコ, 吉澤誠, 本間経康, 杉田典大, 清水一夫, 後藤萌, 稲垣正司, 杉町勝, 砂川賢二. 重回帰分析を用いた致死性不整脈検出アルゴリズムに関する検討. 生体医工学48:577-583, 2010
21. Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S. Structural heterogeneity in the ventricular wall plays a significant role in the initiation of stretch-induced arrhythmias in perfused rabbit right ventricular tissues and whole heart preparations. Circulation Research106(1):176-184, 2010.
22. Sugai TK, Yoshizawa M, Abe M, Shimizu K, Inagaki M, Sugimachi M, Sunagawa K. Preliminary study on the detection of cardiac arrhythmias based on multiple simultaneous electrograms. Conference proceedings - IEEE engineering in medicine and biology society 2009:2498-2501, 2009.
23. Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure. Conference proceedings - IEEE engineering in medicine and biology society 2009:2365-2368, 2009.
24. Sugimachi M, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs. Conference proceedings - IEEE engineering in medicine and biology society 2009:2030-2032, 2009.
25. 瀬尾 欣也, 稲垣 正司, 平 林 智子, 日高 一郎, 杉町 勝, 杉浦 清了, 久田 俊明. 心臓の機械的伸展により誘発される不整脈の機序解明のための医工学的アプローチ. 生体医工学 47:77-87, 2009.
26. Ogoh S, Hayashi N, Inagaki M, Ainslie PN, Miyamoto T. Interaction between the ventilatory and cerebrovascular responses to hypo- and hypercapnia at rest and during exercise. Journal of Physiology 586(17):4327-4338, 2008.
27. Hirabayashi S, Inagaki M, Hisada T. Effects of wall stress on the dynamics of ventricular fibrillation: a simulation study using a dynamic mechanoelectric model of ventricular tissue. Journal of Cardiovascular Electrophysiology 19(7):730-739, 2008.
28. Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K, Sugimachi M. Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit. American Journal of Physiology - Heart and Circulatory Physiology 293(4):H2254-2261, 2007.
29. Aiba T, Shimizu W, Hidaka I, Uemura K, Noda T, Zheng C, Kamiya A, Inagaki M, Sugimachi M, Sunagawa K. Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study. Journals of the American College of Cardiology 47(10):2074-2085, 2006.
30. Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M. Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. American Journal of Physiology - Heart and Circulatory Physiology 291(1):H318-326, 2006.
31. Hamamoto M, Tomita S, Inagaki M, Yutani C, Yamashiro S, Sunagawa K, Nakatani T, Kitamura S. Bone marrow cell transplantation into the heart is not a critical factor of ventricular fibrillation in a rat doxorubicin-induced cardiomyopathy model. Journal of Arrhythmia 22(2):86-91, 2006.
32. Seo K, Inagaki M, Hirabayashi S, Sugimachi M, Hisada T. Inhomogeneous structure of ventricular walls contributes to stretch-induced arrhythmia. Circulation 114(Suppl.18), 2006.
33. Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding WG, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil. Journals of the American College of Cardiology 45(2):300-307, 2005.
34. Inagaki M, Kawada T, Lie M, Zheng C, Sunagawa K, Sugimachi M. Intravascular parasympathetic cardiac nerve stimulation prevents ventricular arrhythmias during acute myocardial ischemia. Conference proceedings - IEEE engineering in medicine and biology society 7(1):7076-7079, 2005.
35. Zheng C, Li M, Inagaki M, Kawada T, Sunagawa K, Sugimachi M. Vagal stimulation markedly suppresses arrhythmias in conscious rats with chronic heart failure after myocardial infarction. Conference proceedings - IEEE engineering in medicine and biology society 7(1):7072-7075, 2005.
36. Yoshizawa M, Inagaki M, Uemura K, Sugimachi M, Sunagawa K. Development of detection algorithm of fatal arrhythmia for a new implantable cardioverter defibrillator. Conference proceedings - IEEE engineering in medicine and biology society 4:3909-3912, 2005.
著書総説・著書
1. Hirabayashi S, Inagaki M, Hisada T, Sugimachi M. Effects of wall stress on the dynamics of ventricular fibrillation: a computer simulation study of mechanoelectric feedback. Mechanosensitivity of the Heart (Mechanosensitivity in Cells and Tissues 3):387-419, 2009.
2. 佐藤博司, 稲垣正司, 林拓也, 飯田秀博．Diffusion MRI. CARDIAC PRACTICE 18(3):201-204, 2007.
3. 稲垣正司, 杉町勝, 砂川賢二. ペースメーカー治療の将来．Heart View 11(6):647-653, 2007.
4. 稲垣正司, 砂川賢二．循環の制御．計測と制御46(10)：808-814, 2007.
5. 杉町勝, 稲垣正司, 砂川賢二. シミュレーションにより致死性不整脈のリスクを評価する―その具体的戦略―．なぜ不整脈は起こるのか―心筋活動電位からスパイラルリエントリーまで― : 194-202, 2006.
6. Suzuki T, Ashihara T, Inagaki M, Namba T, Ikeda T, Nakazawa K. A High-performance Computation Method for Simulation of Cardiac Excitation Propagation using a Supercomputer. Clinical Application of Computational Mechanics to the Cardiovascular System:193-204, 2000.
7. Ashihara T, Suzuki T, Namba T, Inagaki M, Ikeda T, Ito N, Kinoshita M, Nakazawa K. Simulated Electrocardiogram of Spiral Wave Reentry in a Mathematical Ventricular Model. Clinical Application of Computational Mechanics to the Cardiovascular System:205-216, 2000.
8. Nakazawa K, Suzuki T, Ashihara T, Inagaki M, Namba T, Ikada T, Suzuki R. Computational Analysis and Visualization of Spiral Wave Reentry in a Virtual Heart Model. Clinical Application of Computational Mechanics to the Cardiovascular System:217-241, 2000.
9. 稲垣正司. Ⅲ群抗不整脈薬をどのように使いこなすか. Cardiologist 2:93-98, 1997.
10. 稲垣正司, 鎌倉史郎. 房室結節性頻拍の鑑別困難例に対する工夫. Heart View 1:159-163, 1997.
11. 稲垣正司, 鎌倉史郎. 心房粗・細動に対するカテーテルアブレーション. 呼吸と循環 44(11):1147-1153, 1996.
12. 稲垣正司, 大江透. 不整脈の非薬物療法はどこまで進歩したか. 循環器NOW 不整脈 8:31-39, 1995.
13. 稲垣正司, 大江透. 不整脈の見つけ方と見分け方. 臨床透析 10:425-432, 1994.
14. 稲垣正司, 大江透. 不整脈による突然死は予知できるか－有用性と限界－：電気生理学的検査. 臨床成人病 23:281-286, 1993.
15. 稲垣正司, 大江透. 心室頻拍のマネージメント. CURRENT THERAPY 10:119-123, 1992.
循環器内科 部長 氏野 経士 Keiji Ujino
論文
1. Ujino K, Barnes ME, Cha SS, Langins A.P, Bailey KR, Seward JB, Tsang TSM. Two-dimensional echocardiographic methods for assessment of left atrial volume. American Journal of Cardiology 98(9):1185-1188, 2006.
2. Ujino K, Hillis GS, Mulvagh SL, Hagen ME, Oh JK. Usefulness of real-time intravenous myocardial contrast echocardiography in predicting left ventricular dilation after successfully reperfused acute myocardial infarction. American Journal of Cardiology 96(1):17-21, 2005.
3. Ujino K, Teragaki M, Ota T, Muro T, Watanabe H, Yoshiyama M, Takeuchi K, Yoshikawa J. Novel method for assessing myocardial perfusion: visualization and measurement of intramyocardial coronary blood flow in the entire left ventricular wall using contrast enhanced, high frequency Doppler echocardiography. Japanese heart journal 42(1):101-13, 2001.
循環器内科 副部長 竹田 光男 Mitsuo Takeda
論文
1. Matsunaga S, Okigaki M, Takeda M, Matsui A, Honsho S, Katsume A, Kishita E, Che J, Kurihara T, Adachi Y, Mansukhani A, Kobara M, Matoba S, Tatsumi T, Matsubara H. Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction. Journal of Molecular and Cellular Cardiology 46(5):663-673, 2009.
2. Takeda M, Tatsumi T, Matsunaga S, Hayashi H, Kimata M, Honsho S, Nishikawa S, Mano A, Shiraishi J, Yamada H, Takahashi T, Matoba S, Kobara M, Matsubara H. Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts. Hypertension Research 30(5):427-437, 2007.
循環器内科 副部長 桑木 恒 Hiroshi Kuwaki
論文
1. Kuwaki H, Sagara A, Sugatani S, Uchida Y, Takemura N, Ujino K. Novel Method of Administering Pharyngeal Anesthesia before Transesophageal Echocardiography. J Am Soc Echocardiogr. 2021 Jul;34(7):794-795. doi: 10.1016/j.echo.2021.02. 009. Epub 2021 Feb 16.
2. Kuwaki H, Yamashita H, Shimada Y, Ujino K. Giant left atrial septal pouch stained during trans-septal puncture.BMJ Case Rep. 2020 Dec 31;13(12):e240128. doi: 10.1136/bcr-2020-240128.
3. Hei S, Iwataki M, Jang JY, Kuwaki H, Fukuda S, Kim YJ, Toki M, Onoue T, Hayashi A, Nishino S, Watanabe N, Hayashida A, Tsuda Y, Araki M, Nishimura Y, Song JK, Yoshida K, Levine RA, Otsuji Y. Relations of Augmented Systolic Annular Expansion and Leaflet/Papillary Muscle Dynamics in Late-Systolic Mitral Valve Prolapse Evaluated by Echocardiography with a Speckle Tracking Analysis. International Heart Journal 61(5):970-978, 2020.
5. Hei S, Iwataki M, Jang JY, Kuwaki H, Mahara K, Fukuda S, Kim YJ, Nabeshima Y, Onoue T, Nagata Y, Nishino S, Watanabe N, Takeuchi M, Nishimura Y, Song JK, Levine RA, Otsuji Y. Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction. American Journal of Physiology-Heart and Circulatory Physiology 316(3):H629-H638, 2019.
6. Fukuda S, Song JK, Mahara K, Kuwaki H, Jang JY, Takeuchi M, Sun BJ, Kim YJ, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Basal Left Ventricular Dilatation and Reduced Contraction in Patients with Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction. Circulation: Cardiovascular Imaging 9(10): e005113, 2016.
7. Takeuchi M, Kuwaki H, Wu VC, Otsuji Y. Reply: Is new grade Ia of diastolic dysfunction relevant at the population level?. JACC: Cardiovascular Imaging 8(2):229-230, 2015.
8. Kuwaki H, Takeuchi M, Chien-Chia Wu V, Otani K, Nagata Y, Hayashi A, Iwataki M, Fukuda S, Yoshitani H, Abe H, Otsuji Y. Redefining diastolic dysfunction grading: combination of E/A ≤0.75 and deceleration time >140 ms and E/ε' ≥10. JACC: Cardiovascular Imaging 7(8):749-758, 2014.
9. Wu VC, Takeuchi M, Kuwaki H, Iwataki M, Nagata Y, Otani K, Haruki N, Yoshitani H, Tamura M, Abe H, Negishi K, Lin FC, Otsuji Y. Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: comparison with 2D echocardiography. JACC: Cardiovascular Imaging 6(10):1025-1035, 2013.
10.Haruki N, Takeuchi M, Yoshitani H, Otani K, Kuwaki H, Iwataki M, Abe H, Tamura M, Okazaki M, Otsuji Y. Immediate amelioration of mechanical pulsus alternans by adaptive servo-ventilation therapy. Heart, Lung and Circulation 22(4):300-302, 2013.
11.Iwataki M, Takeuchi M, Otani K, Kuwaki H, Haruki N, Yoshitani H, Tamura M, Abe H, Otsuji Y. Measurement of left atrial volume from transthoracic three-dimensional echocardiographic datasets using the biplane Simpson's technique. Journal of the American Society of Echocardiography 25(12):1319-1326, 2012.
12.Haruki N, Takeuchi M, Kaku K, Yoshitani H, Kuwaki H, Tamura M, Abe H, Okazaki M, Tsutsumi A, Otsuji Y. Comparison of acute and chronic impact of adaptive servo-ventilation on left chamber geometry and function in patients with chronic heart failure. European Journal of Heart Failure 13(10):1140-1106, 2011.
13.Kuwaki H, Takeuchi M, Kaku K, Haruki N, Yoshitani H, Tamura M, Okazaki M, Abe H, Otsuji Y. Thrombus attached to the left atrial septal pouch assessed on 3-dimensional transesophageal echocardiography. Circulation Journal 75(9):2280-2281,2011.
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